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Hiroshi Otsubo Selected Research

Hemispherectomy

8/2017The Fault in Their Stars-Accumulating Astrocytic Inclusions Associated With Clusters of Epileptic Spasms in Children With Global Developmental Delay.
1/2017Epileptogenic high-frequency oscillations skip the motor area in children with multilobar drug-resistant epilepsy.
4/2016Utility of diffusion tensor imaging studies linked to neuronavigation and other modalities in repeat hemispherotomy for intractable epilepsy.
12/2011The role of magnetoencephalography in children undergoing hemispherectomy.
12/2010Hemispherectomy for the control of intractable epilepsy in childhood: comparison of 2 surgical techniques in a single institution.
12/2006[History of epilepsy surgery at The Hospital for Sick Children in Toronto, Canada].

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Hiroshi Otsubo Research Topics

Disease

25Epilepsy (Aura)
11/2021 - 06/2002
21Seizures (Absence Seizure)
01/2021 - 01/2002
16Drug Resistant Epilepsy
10/2022 - 01/2005
9Partial Epilepsies (Epilepsy, Partial)
10/2022 - 05/2003
6Tuberous Sclerosis (Bourneville's Disease)
11/2016 - 09/2005
4Status Epilepticus (Complex Partial Status Epilepticus)
01/2021 - 04/2007
4Infantile Spasms (West Syndrome)
01/2019 - 03/2003
4Spasm (Spasms)
01/2018 - 12/2005
3Sudden Unexpected Death in Epilepsy
01/2020 - 11/2017
2Lennox Gastaut Syndrome
01/2015 - 05/2010
2Malformations of Cortical Development
04/2003 - 05/2002
1Critical Illness (Critically Ill)
01/2021
1Frontal Lobe Epilepsy (Epilepsy, Supplementary Motor)
01/2021
1Focal cortical dysplasia of Taylor
01/2019
1Intellectual Disability (Idiocy)
01/2019
1Williams Syndrome (Williams-Beuren Syndrome)
12/2018
1Disease Progression
07/2014
1Idiopathic Generalized Epilepsy
07/2011
1Absence Epilepsy (Childhood Absence Epilepsy)
07/2011
1Hydrocephalus (Hydrocephaly)
12/2010
1Aplastic Anemia (Anemia, Hypoplastic)
05/2010
1Liver Failure
05/2010
1Craniocerebral Trauma (Head Injury)
06/2008
1Coma (Comas)
06/2008
1Temporal Lobe Epilepsy
12/2006
1Paresis (Hemiparesis)
12/2006
1Hippocampal Sclerosis
12/2006
1Glioma (Gliomas)
12/2005
1Precocious Puberty
05/2005
1Porencephaly
01/2005
1Autistic Disorder (Autism)
03/2003
1Aphasia (Dysphasia)
01/2002

Drug/Important Bio-Agent (IBA)

7Anticonvulsants (Antiepileptic Drugs)IBA
01/2019 - 01/2002
7trans-sodium crocetinate (crocetin)IBA
11/2016 - 09/2005
6Biomarkers (Surrogate Marker)IBA
01/2021 - 11/2017
4Pharmaceutical PreparationsIBA
01/2021 - 12/2006
2Adrenocorticotropic Hormone (ACTH)FDA Link
01/2017 - 03/2003
2Proteins (Proteins, Gene)FDA Link
03/2012 - 07/2008
2VigabatrinFDA Link
05/2010 - 03/2003
1Brain-Derived Neurotrophic Factor (BDNF)IBA
01/2016
1N'-geranylpiperazinylfarnesyl acetamideIBA
01/2015
1Kainic Acid (Kainate)IBA
01/2014
1Propofol (Diprivan)FDA LinkGeneric
08/2013
1Deoxyglucose (2 Deoxy D glucose)IBA
04/2013
1Phenobarbital (Luminal)FDA Link
11/2011
1Immunoglobulin E (IgE)IBA
07/2011
1fosphenytoin (Cerebyx)FDA LinkGeneric
05/2010
1gamma-Aminobutyric Acid (GABA)IBA
05/2010
1Hypnotics and Sedatives (Sedatives)IBA
05/2010
1Lorazepam (Ativan)FDA LinkGeneric
05/2010
1ProdrugsIBA
05/2010
1BenzodiazepinesIBA
05/2010
1Valproic Acid (Depakote)FDA LinkGeneric
05/2010
1Oxcarbazepine (Trileptal)FDA LinkGeneric
05/2010
1Felbamate (Felbatol)FDA Link
05/2010
1Tiagabine (Gabitril)FDA Link
05/2010
1Zonisamide (Zonegran)FDA LinkGeneric
05/2010
1Levetiracetam (Keppra)FDA LinkGeneric
05/2010
1Topiramate (Topamax)FDA LinkGeneric
05/2010
1Lamotrigine (Lamictal)FDA LinkGeneric
05/2010
1Gabapentin (Neurontin)FDA LinkGeneric
05/2010
1rufinamideFDA Link
05/2010
1FilaminsIBA
07/2008
1Dexamethasone (Maxidex)FDA LinkGeneric
01/2006
1SteroidsIBA
01/2006
1Gonadotropin-Releasing Hormone (GnRH)FDA Link
05/2005
1Adrenal Cortex Hormones (Corticosteroids)IBA
03/2003

Therapy/Procedure

13Electrodes (Electrode)
10/2022 - 05/2002
6Hemispherectomy
08/2017 - 12/2006
4Implanted Electrodes
10/2022 - 11/2013
4Operative Surgical Procedures
12/2010 - 05/2003
3Therapeutics
11/2021 - 04/2007
3Vagus Nerve Stimulation
01/2021 - 11/2019
3Intravenous Anesthesia
08/2013 - 06/2008
3Neurosurgical Procedures
12/2011 - 12/2006
2Anesthesia
01/2019 - 06/2008
2Anterior Temporal Lobectomy
04/2007 - 12/2006
1Ketogenic Diet
12/2018
1Electrocoagulation (Electrocautery)
08/2017
1Intraperitoneal Injections
01/2014
1Injections
05/2010
1Off-Label Use
05/2010
1Intravenous Administration
05/2010
1Critical Care (Surgical Intensive Care)
06/2008
1Surgical Instruments (Clip)
12/2005